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Recent increase in antibiotic-resistant microorganisms in patients with spontaneous bacterial peritonitis adversely

Young Hwan Park1, Han Chu Lee, Hee Gon Song

  • 1Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Journal of Gastroenterology and Hepatology
|July 16, 2003
PubMed
Abstract

Insights

Antibiotic resistance in spontaneous bacterial peritonitis (SBP) is rising in Korea. This trend correlates with increased treatment failure and necessitates stricter antibiotic stewardship to prevent the spread of resistant bacteria.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Microbiology

Background:

  • Increasing prevalence of antibiotic-resistant microorganisms in Korean patients with spontaneous bacterial peritonitis (SBP).
  • Need to understand the evolving patterns of antibiotic resistance in SBP management.

Purpose of the Study:

  • To investigate the changing patterns of antibiotic resistance in SBP.
  • To evaluate the impact of antibiotic resistance on clinical outcomes in SBP patients.

Main Methods:

  • Retrospective analysis of SBP episodes from 1995, 1998, and 1999.
  • Comparison of isolated microorganisms and their antibiotic susceptibility.
  • Analysis of prognostic factors influencing survival in SBP.

Main Results:

  • Gram-negative bacilli resistance to cefotaxime increased from 7% (1995) to 28% (1999); ciprofloxacin resistance rose from 10% to 32%.
  • Treatment failure rates in SBP increased from 6% to 23% during the study period.
  • Hepatocellular carcinoma and SBP caused by extended-spectrum beta-lactamase-producing strains were independent negative prognostic factors.

Conclusions:

  • Significant increase in antibiotic resistance observed in SBP pathogens.
  • Urgent need for stringent measures to prevent in-hospital transmission of resistant strains.
  • Call for more judicious antibiotic use to combat rising resistance in SBP.

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