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Interferons and apoptosis.

Michael J Clemens1

  • 1Translational Control Group, Department of Basic Medical Sciences, St. George's Hospital Medical School, London SW17 0RE, UK. M.Clemens@sghms.ac.uk

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
|July 16, 2003
PubMed
Summary
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Interferons (IFNs) control cell proliferation and survival by influencing apoptosis. This review explores how IFNs synergize with other agents to impact viral infections and tumor growth.

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • Interferons (IFNs) possess known antiviral properties.
  • IFNs also regulate cell proliferation, division, and survival.
  • Their role in apoptosis is crucial for managing viral infections and cancer.

Purpose of the Study:

  • To review the mechanisms of Interferon action on apoptosis.
  • To highlight the synergistic effects of IFNs with proapoptotic agents.
  • To discuss the implications for viral infection and tumor growth regulation.

Main Methods:

  • Literature review of Interferon (IFN) mechanisms.
  • Analysis of cytokine interactions with apoptotic pathways.
  • Examination of synergistic effects with tumor necrosis factor (TNF) family members.

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Main Results:

  • IFNs modulate apoptotic machinery through complex signaling pathways.
  • Synergism between IFNs and TNF family members enhances apoptosis.
  • These interactions have significant physiological and clinical relevance.

Conclusions:

  • Interferons play a critical role in regulating apoptosis.
  • Understanding IFN-mediated apoptosis is key for developing therapies against viral diseases and cancers.
  • Targeting IFN-induced apoptosis offers potential for novel treatment strategies.