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Related Experiment Videos

[Analysis of CD117 expression on leukemia cells].

Hong-qiang Shen1, Yong-min Tang, Shi-long Yang

  • 1Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.

Zhonghua Xue Ye Xue Za Zhi = Zhonghua Xueyexue Zazhi
|July 16, 2003
PubMed
Summary

CD(117) expression is frequent in myeloid leukemias like AML and CML-BC, but rare in lymphoid leukemias. This marker aids in differentiating leukemia types and clones.

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Area of Science:

  • Hematology
  • Immunophenotyping
  • Cancer Biology

Context:

  • Leukemia classification relies on immunophenotypic markers.
  • CD(117) is a tyrosine kinase receptor with known roles in hematopoiesis.
  • Understanding CD(117) expression patterns can refine diagnostic approaches.

Purpose:

  • To investigate the differential expression of CD(117) across various leukemia subtypes.
  • To assess the diagnostic significance of CD(117) in distinguishing myeloid from lymphoid leukemias.

Summary:

  • CD(117) was detected in 68% of acute myeloid leukemia (AML) and 80% of chronic myeloid leukemia in blast crisis (CML-BC) cases.
  • Expression was significantly lower in acute lymphoblastic leukemia (2%) and absent in chronic phase CML and chronic lymphocytic leukemia.

Related Experiment Videos

  • CD(117) showed varied expression within AML subtypes, with higher prevalence in M(2), M(6), and M(7), and an inverse correlation with CD(14).

    • Impact:

    • CD(117) immunophenotyping can aid in distinguishing myeloid from lymphoid leukemia.
    • This marker may assist in differentiating leukemic clones from normal hematopoietic cells.
    • Findings contribute to improved diagnostic accuracy and potential therapeutic targeting in leukemia.