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Antigenic Liposomes for Generation of Disease-specific Antibodies
10:31

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Published on: October 25, 2018

Lipopeptide adjuvants in combination treatment

Wolfgang G Bessler1, K Mittenbühler, U v d Esche

  • 1Institut für Molekulare Medizin und Zellforschung, Universitätsklinikum Freiburg, Stefan-Meier-Str. 8, D-79104 Fribourg, Germany. wolfgang.bessler@mol-med.uni-freiburg.de

International Immunopharmacology
|July 16, 2003
PubMed

Synthetic lipopeptides derived from the N-terminus of bacterial lipoprotein constitute potent immunoadjuvants for parenteral and mucosal immunization. When combined with tetanus toxoid (TT) or gliadin as antigens, the lipopeptide N-palmitoyl-S-[2,3-bis(palmitoyloxy)-(2RS)-propyl]-(R)-cysteinyl-seryl-(lysyl)(3)-lysine (P(3)CSK(4)) markedly enhanced the specific antibody levels. Lipopeptides also act as macrophage/monocyte activators: P(3)CSK(4) induced nitric oxide release from bone marrow-derived macrophages (BMDM) of LPS responder and nonresponder mice. The antitumoral effect of the lipopeptide was demonstrated by a strong cytostatic activity of the lipopeptide-treated macrophages against the murine B-cell lymphoma cell line Abelson 8-1. The chemically well-defined lipopeptides can be synthesized with high purity and reproducibility and constitute ideal agents to be combined with antigens/vaccines or antitumor treatment.

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