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Placental angiotensin II receptor AT1R in normotensive patients and its correlation between infant birth weight
Marzena Laskowska1, Bozena Leszczyńska-Gorzelak, Jan Oleszczuk
1Department of Obstetrics and Perinatology, University School of Medicine in Lublin, Jaczewskiego 8, Lublin 20-950, Poland. marzena@asklepios.am.lublin.pl
Objective:
To evaluate angiotensin II type 1 receptor (AT1R) in the third trimester placenta from normotensive women and the correlation between placental AT1R immunoreactivity and infant birth weight.
Patients And Methods:
The study was carried out on 18 healthy normotensive patients with singleton uncomplicated pregnancies. Immunohistochemistry was used to examine the localization of AT1R in the human placenta.
Results:
Immunohistochemistry using a monoclonal antibody showed that angiotensin II (Ang II) receptor subtype 1 is localized in the decidual cells, syncytiotrophoblast, cytotrophoblast, Hofbauer cells and vascular endothelium. In our study group of patients, we found a significant negative correlation between histological staining in placental tissue and infant birth weight.
Conclusion:
It seems that the appropriate placental AT1R expression and its normal vascular and endocrine activity plays a very important role in oxygenation and nutrition of the fetus and this ensures proper fetal development and growth.
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