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Published on: March 8, 2012
Cervical response to vaccination against HPV16 E7 in case of severe dysplasia
1Department of Obstetrics and Gynaecology, CUB Hopital Erasme, Route de Lennik 808, 1070 Brussels, Belgium. psimon@ulb.ac.be
Objective:
To evaluate the tolerance to vaccination against human papillomavirus (HPV)16 E7 (in SB adjuvant ASO2B) and its histological and immunohistological effects on HPV16 associated high-grade cervical dysplasias associated with HPV16.
Study Design:
Five patients with histologically demonstrated severe cervical dysplasia (CIN3) HPV16 positive were injected three times before conization was performed 2 months after the first injection. We studied cytological, histological, proliferative pattern and immune profile before and after vaccination. The slides were compared with those obtained from non-injected patients.
Results:
The injections were well tolerated and the specimens displayed a limited regression of the lesions. Nevertheless, massive CD4 and CD8 T cell lymphocytic infiltration was noticed after vaccination.
Discussion:
We conclude that the vaccination we used provides an obvious immune histological reaction in the HPV infected cervix and that the 2 months delay before the final step (conization) is done is probably too short.
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