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Related Experiment Videos

Antiphospholipid antibody in localised scleroderma.

S Sato1, M Fujimoto, M Hasegawa

  • 1Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan. s-sato@med.kanazawa-u.ac.jp

Annals of the Rheumatic Diseases
|July 16, 2003
PubMed
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Antiphospholipid antibodies, including anticardiolipin (aCL) and lupus anticoagulant (LAC), are prevalent in generalised morphoea, a severe form of localised scleroderma. These autoantibodies correlate with disease severity and associated immunological markers.

Area of Science:

  • Rheumatology
  • Immunology
  • Dermatology

Background:

  • Localised scleroderma encompasses conditions like morphoea and linear scleroderma.
  • Antiphospholipid antibodies are implicated in autoimmune and thrombotic disorders.

Purpose of the Study:

  • To determine the prevalence of antiphospholipid antibodies in localised scleroderma.
  • To explore the clinical and immunological correlations of these antibodies.

Main Methods:

  • Enzyme-linked immunosorbent assay (ELISA) was used to detect antibodies against cardiolipin (aCL) and beta(2)-glycoprotein I.
  • Coagulation tests identified lupus anticoagulant (LAC).
  • 48 patients with localised scleroderma were studied, along with control groups.

Main Results:

Related Experiment Videos

  • Elevated IgM or IgG anticardiolipin (aCL) antibodies were found in generalised morphoea patients compared to controls and systemic sclerosis patients.
  • IgM aCL was predominant and associated with more extensive lesions and other immunological abnormalities.
  • Lupus anticoagulant (LAC) was detected in a majority of generalised morphoea patients, though clinical thrombosis was rare.

Conclusions:

  • Anticardiolipin (aCL) antibodies and lupus anticoagulant (LAC) are significant autoantibodies in generalised morphoea.
  • These findings highlight a potential autoimmune component in the pathogenesis of severe localised scleroderma.