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Updated: Sep 23, 2026

Establishment and Evaluation of a Risk Prediction Model for Pathological Escalation of Gastric Low-Grade Intraepithelial Neoplasia
Published on: February 16, 2024
Gastric surgery as a long-term risk factor for malignant lesions of the larynx
Rossella Cianci1, Jacopo Galli, Stefania Agostino
1Department of Internal Medicine and Gastroenterology, Catholic University of Medicine and Surgery, Rome, Italy.
Background:
Duodenogastroesophageal reflux is common after total or partial gastrectomy. No data are available on the effect of duodenal reflux on the larynx.
Hypothesis:
Premalignant or malignant changes occur more frequently among subjects with gastric surgery.
Design:
Historical cohort study.
Setting:
Outpatient setting for upper endoscopy.
Patients:
Ninety-three subjects who had undergone gastric resection at least 5 years previously, and 93 matched dyspeptic individuals who did not undergo gastric surgery.
Intervention:
Clinical histories of all patients were obtained and recorded. All subjects underwent an otolaryngologic evaluation.
Results:
Of 93 patients with gastric resection, 7 patients had current or previous laryngeal malignancies or current precancerous mucosal changes. In the control group, 1 subject had a leukoplakia on the vocal cord. The adjusted odds ratio (having included sex, age, and alcohol [yes or no] and smoking [yes or no] history in the regression model) was 9.88 (95% confidence interval, 1.01-97.31; likelihood ratio chi2 = 28.77; P<.001). Furthermore, there was a significant increased prevalence of benign laryngeal lesions in patients with gastric resection vs the control group.
Conclusions:
The risk of developing laryngeal malignancies is higher for patients with gastric resection. A periodic otolaryngologic evaluation in subjects with gastric surgery may contribute to early diagnosis of laryngeal disorders.
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