Related Experiment Video

Updated: Aug 16, 2026

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
06:34

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

QT dispersion and left ventricular morphology in patients with hypertrophic cardiomyopathy

K Sakata1, M Shimizu, H Ino

  • 1Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.

Heart (British Cardiac Society)
|July 16, 2003
PubMed

Insights

QT dispersion, a measure of heart electrical activity, is higher in hypertrophic cardiomyopathy patients with uneven septal thickening. This suggests morphology impacts electrical patterns.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Cardiac Imaging

Background:

  • Hypertrophic cardiomyopathy (HCM) is a genetic heart muscle disease.
  • Left ventricular hypertrophy (LVH) is a hallmark of HCM.
  • The distribution of LVH can vary, potentially influencing cardiac electrical activity.

Purpose of the Study:

  • To investigate the relationship between QT interval variables and the pattern of left ventricular wall hypertrophy in patients with HCM.
  • To determine if specific patterns of hypertrophy are associated with altered electrical dispersion.

Main Methods:

  • Retrospective analysis of echocardiography and electrocardiography data from 70 HCM patients.
  • Patients were categorized into four groups based on the distribution of LVH.
  • QT intervals and QT dispersion were measured from 12-lead ECGs.

Main Results:

  • No significant differences in maximum left ventricular wall thickness or QTc intervals were observed across groups.
  • QTc dispersion and JTc dispersion were significantly increased in groups with septal-predominant hypertrophy (Groups A and B).
  • QTc and JTc dispersions correlated with the ratio of interventricular septal thickness to left ventricular posterior wall thickness.

Conclusions:

  • QT dispersion in HCM is influenced by both electrical and morphological inhomogeneity of the left ventricle.
  • The pattern of LVH, particularly septal involvement, may contribute to increased ventricular electrical heterogeneity.
Abstract

More Related Videos

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography07:11

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography

Published on: October 28, 2020

An Approach to Study Shape-Dependent Transcriptomics at a Single Cell Level06:02

An Approach to Study Shape-Dependent Transcriptomics at a Single Cell Level

Published on: November 2, 2020

Related Concept Videos

Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...