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Updated: Sep 23, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
Published on: February 8, 2019
Generalized vasculitis, thrombocytopenia, and transient lymphoproliferative disorder caused by idiopathic mixed
Shmuel Schwartzenberg1, Yoram Levo, Mordechai Averbuch
1Department of Medicine T, Tel Aviv Souraski Medical Center, Israel.
Abstract:
We present a 75-year-old patient with recurrent palpable purpura and multiorgan involvement by leukocytoclastic vasculitis caused by mixed-type cryoglobulinemia. The disease spanned 40 years, with many flare-ups, each associated with thrombocytopenia, and finally culminated in widespread involvement of not only the skin and the kidneys but also the lungs and spleen. Despite extensive investigation, no association with hepatitis C virus or with any malignant or connective tissue disorder was found.
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