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Characterization of sulphoalkyl ether derivatives of beta-cyclodextrin by capillary electrophoresis with indirect UV
R J Tait1, D J Skanchy, D P Thompson
1Center for Drug Delivery Research, University of Kansas, Lawrence 66045.
Journal of Pharmaceutical and Biomedical Analysis
|September 1, 1992
Abstract:
A capillary electrophoresis method which characterizes the degrees of substitution of heterogeneous sulphoalkyl ether beta-cyclodextrin derivatives is described. The separation is based on the different electrophoretic mobilities observed from changes in the overall charge of the molecule as a result of substitution. Individual peaks of the electropherogram then provide a measure of each degree of substitution of the present beta-cyclodextrin. Detection of these beta-cyclodextrin derivatives is performed by indirect UV detection.