Search research articles

Search research articles

Related Experiment Videos

Recent advances against substance abuse.

Christine E Heading¹

¹The Open University, Department of Biological Sciences, Walton Hall, Milton Keynes, MK7 6AA, UK. moore11@globalnet.co.uk

Idrugs : the Investigational Drugs Journal

|July 16, 2003

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Gender issues and the pharmacotherapy of substance abuse.

IDrugs : the investigational drugs journal·2008

Same author

Drug evaluation: CYT-002-NicQb, a therapeutic vaccine for the treatment of nicotine addiction.

Current opinion in investigational drugs (London, England : 2000)·2007

Same author

Vivitrex (Alkermes/Cephalon).

Current opinion in investigational drugs (London, England : 2000)·2006

Same author

Conus toxins: targets and properties.

IDrugs : the investigational drugs journal·2004

Same author

NicVAX (Nabi Biopharmaceuticals).

IDrugs : the investigational drugs journal·2003

Same author

TA-CD. Xenova.

IDrugs : the investigational drugs journal·2003

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Pharmacotherapy for substance abuse, including novel long-acting formulations and vaccines, is advancing to aid patient compliance and prevent relapse. Research focuses on targeting use-reinforcement pathways and dopamine systems, particularly for cocaine abuse.

Area of Science:

Pharmacology
Neuroscience
Addiction Medicine

Background:

Pharmacotherapy for substance abuse often requires integrated psychosocial support.
Patient needs evolve through cycles of use and abstinence, necessitating adaptable treatment.
Compliance is a significant challenge in substance abuse treatment.

Purpose of the Study:

To review current and emerging pharmacotherapies for substance abuse.
To highlight advancements in long-acting formulations and novel therapeutic targets.
To discuss the specific focus on dopamine system targets for cocaine abuse.

Main Methods:

Review of current literature on pharmacotherapy for substance abuse.
Analysis of emerging drug development pipelines, including long-acting formulations, reinforcement pathway inhibitors, and vaccines.

Related Experiment Videos

Examination of research trends in cocaine abuse pharmacotherapy.

Main Results:

Long-acting agonist and antagonist formulations are being developed for substitution and relapse prevention.
Novel products targeting use-reinforcement pathways are in clinical trials.
Vaccines to prevent abused substances from reaching the brain are under development.
Dopamine reuptake system targets are a primary focus for cocaine abuse pharmacotherapy.

Conclusions:

Pharmacotherapy for substance abuse is evolving with innovative formulations and targets.
Matching pharmacotherapy to patient needs throughout their recovery journey is crucial.
Future treatments may include substitution, relapse prevention, reinforcement pathway modulation, and preventative vaccines.