Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Necrotizing enterocolitis in full-term infants.

Daniel J Ostlie1, Troy L Spilde, Shawn D St Peter

  • 1Department of Surgery, The Children's Mercy Hospital, Kansas City, MO 64108, USA.

Journal of Pediatric Surgery
|July 16, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MYCN drives pediatric glioma transformation from neural progenitors and creates distinct therapeutic vulnerabilities.

Cell reports·2026
Same author

Alpha-cell glucagon is essential for maintaining β-cell function and identity in adult mice.

The Journal of biological chemistry·2026
Same author

Infections following minimally invasive repair of pectus excavatum in pediatric patients: a multi-institutional retrospective cohort study of the Western Pediatric Surgery Research Consortium.

Pediatric surgery international·2026
Same author

Editorial: Advances in β-cell development & regeneration.

Frontiers in endocrinology·2026
Same author

The Stathmin 1-lineage Contributes to Acinar Regeneration but Not to Neoplasia Upon Oncogenic Kras Expression.

Cellular and molecular gastroenterology and hepatology·2026
Same author

Western pediatric cervical spine study: an observational prospective Western Pediatric Surgery Research Consortium and Western Trauma Association multicenter study protocol.

Trauma surgery & acute care open·2026

Necrotizing enterocolitis (NEC) in full-term infants presents differently than in preterm infants, often diagnosed earlier and linked to cardiac disease. Outcomes for full-term infants with NEC are similar to preterm infants.

Area of Science:

  • Neonatal Medicine
  • Pediatric Surgery
  • Gastroenterology

Background:

  • Necrotizing enterocolitis (NEC) is predominantly a disease of prematurity, but affects full-term infants in about 10% of cases.
  • Previous research on NEC in full-term (FT) versus preterm (PT) infants has yielded conflicting findings.
  • Identifying factors specific to NEC in full-term neonates is crucial for understanding and managing this condition.

Purpose of the Study:

  • To review necrotizing enterocolitis (NEC) cases over three decades at a single institution.
  • To identify demographic, clinical, and outcome-related factors associated with NEC in full-term (FT) neonates.
  • To compare NEC characteristics and outcomes between full-term (FT) and preterm (PT) infants.

Main Methods:

  • Retrospective chart review of all infants diagnosed with definitive NEC from 1972 to 2001.

Related Experiment Videos

  • Study included 277 infants: 251 preterm (PT) and 26 full-term (FT).
  • Collected data on demographics, clinical presentation, management, outcomes, and predisposing factors for comparison between FT and PT groups.

    • Main Results:

    • Full-term (FT) infants were diagnosed with NEC at a younger age (5 days) compared to preterm (PT) infants (13 days).
    • Enteral nutrition was initiated earlier in FT infants (1.6 days vs. 3.1 days).
    • Cardiac disease was a significantly more common predisposing factor in FT infants (23% vs. 10%), and 62% of FT infants had predisposing factors.

    Conclusions:

    • Full-term (FT) infants with NEC exhibit distinct characteristics compared to preterm (PT) infants, including earlier diagnosis and a higher association with cardiac disease.
    • Earlier feeding initiation in FT infants may correlate with an earlier onset of NEC.
    • The study found no significant difference in survival rates between FT and PT infants with NEC, contrary to some previous reports.