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The preparation of monodisperse biodegradable polyester nanoparticles with a controlled size
Miechel L T Zweers1, Dirk W Grijpma, Gerard H M Engbers
1Department of Polymer Chemistry and Biomaterials, Institute for Biomedical Technology, Faculty of Chemical Technology, University of Twente, PO Box 217, 7500 AE Enschede, The Netherlands.
Abstract:
In local drug delivery, nanoparticles based on biodegradable polymers can function as vehicles with controlled drug-release properties. To achieve a well-controlled drug-release profile, control over the particle size is of great importance. Therefore, biodegradable polyester nanoparticles were prepared by the salting-out method. Process variables were varied to study the effect on the particle size. The monodisperse particles obtained were between 100 and 400 nm in size and spherical in shape. It was found that the particle size could be adjusted by varying the preparation conditions upon which the polymer concentration had the most pronounced effect.