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[Associated infections in acute bronchopulmonary infections in children]
Abstract:
A total of 189 children with bacterial complications of the acute respiratory viral infection (ARVI)--primarily with pneumonia and bronchitis--were dynamically examined for typical and atypical pneumotropic causative agents of the infection process (Mycoplasma pneumoniae, Chlamydia spp., Streptococcus pneumoniae, Haemophilus influenzae, Pneumocystis carini, and Citomegalovirus). A high frequency rate of the associative infection involving mycoplasmas and pneumocysts was registered (45-50%); it was lower in the cases involving Chlamydias, hemophilic bacteria, pneumococcus, and cytomegalovirus--up to 25-30%. No sharp difference was found between the indices of an infection degree and those of an active clinical infectious process involving the same pneumotropic agent: the biggest difference was observed in Chlamydia infections (9.4%) and the lowest one--in mycoplasma infections (3%). A dynamic comparison of different classes of immunoglobulins revealed that, in acute bronchitis and pneumonias, the Chlamydia and cytomegalovirus infections are, primarily, of the persistent nature; the hemophilic and pneumocystic infections are of a mixed nature; and the pneumococcus one is of the acute nature. The Mycoplasma infection, which is more often encountered in pre-school children, is of the primary type with a trend towards a prolonged clinical course. All pneumonias had a typical clinical course; the clinical picture was compared in 128 patients with the etiological factor (including a description of characteristic symptoms).
Insights
This study examined 189 children with acute respiratory viral infection (ARVI) complications, finding frequent co-infections with Mycoplasma pneumoniae and Pneumocystis. Different pathogens showed varied infection patterns and clinical courses in pediatric pneumonia and bronchitis.
Area of Science:
- Pediatric Infectious Diseases
- Microbiology
- Respiratory Medicine
Context:
- Acute Respiratory Viral Infection (ARVI) frequently leads to secondary bacterial complications in children.
- Understanding the spectrum of pneumotropic pathogens is crucial for effective treatment.
Purpose:
- To dynamically examine typical and atypical pneumotropic agents in children with ARVI complications.
- To analyze the frequency, infection degree, and clinical course of various pathogens including Mycoplasma pneumoniae, Chlamydia spp., Streptococcus pneumoniae, Haemophilus influenzae, Pneumocystis, and Cytomegalovirus.
Summary:
- A study of 189 children revealed high rates (45-50%) of co-infections involving Mycoplasma pneumoniae and Pneumocystis in ARVI complications.
- Chlamydia, Haemophilus influenzae, Streptococcus pneumoniae, and Cytomegalovirus infections were less frequent (up to 25-30%).
- Infections showed distinct patterns: Chlamydia and Cytomegalovirus were persistent, Haemophilus and Pneumocystis were mixed, Streptococcus pneumoniae was acute, and Mycoplasma pneumoniae was primary with a prolonged course.
Impact:
- Identifies common co-infecting agents in pediatric ARVI complications, aiding in diagnosis and management.
- Differentiates infection types (acute, persistent, mixed) and clinical courses based on causative agents.
- Highlights Mycoplasma pneumoniae as a frequent pathogen in preschool children with prolonged respiratory illness.