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Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure
09:37

Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure

Published on: December 2, 2014

[Remodeling myocardium and skeletal muscle in chronic heart failure]

G E Kuznetsov

    Vestnik Rossiiskoi Akademii Meditsinskikh Nauk
    |July 17, 2003
    PubMed

    Insights

    Chronic heart failure (CHF) causes similar tissue and cellular changes in both the heart muscle (myocardium) and skeletal muscles. These changes worsen as CHF progresses, indicating a systemic effect beyond the heart.

    Area of Science:

    • Cardiovascular Biology
    • Skeletal Muscle Physiology
    • Pathology

    Context:

    • Chronic heart failure (CHF) is traditionally studied via myocardial and peripheral vessel remodeling.
    • The adaptive role of remodeling in skeletal muscle during CHF remains unclear.
    • Investigating shared morphological changes is crucial for understanding CHF progression.

    Purpose:

    • To investigate morphological changes in the myocardium and skeletal muscle in CHF patients.
    • To examine the interrelations between myocardial and skeletal muscle conditions in CHF.
    • To compare tissue, cellular, and subcellular changes in both muscle types.

    Summary:

    • Morphological changes in the myocardium and skeletal muscle are similar across tissue, cellular, and subcellular levels in CHF patients.
    • Hypertrophy and fiber heteromorphism increase in both muscle types as CHF severity (NYHA class) advances.
    • A significant correlation (r = 0.57, p < 0.05) exists between the cellular-stromal ratio changes in the myocardium and skeletal muscle.

    Impact:

    • Findings suggest CHF involves systemic skeletal muscle pathology, not just cardiac remodeling.
    • Highlights the potential for shared therapeutic targets for both cardiac and skeletal muscle dysfunction in CHF.
    • Provides novel insights into the pathophysiology of chronic heart failure and its systemic impact.

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