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[Experimental study of corpus cavernosal nerve evoked potential in diabetic rats]
Kai Guo1, Xian-Hui Wang, Yi Wang
1Department of Internal Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610075, China.
Objectives:
To observe the cavernosal nerve dysfunction of diabetic Sprague Dawley rats.
Methods:
Thirty-five Sprague-Dawley rats were divided randomly into diabetes model group(n = 25) and normal group(n = 10). Diabetes model was established by administration of streptozotocin (63 mg/kg) in single intraperitoneal dosing. Giving single wave stimulus, corpus cavernosal nerve was measured for its latent period of reaction and myopotential.
Results:
Compared with other groups, diabetic rats had longer reflection latent period(P < 0.01) and higher corpus cavernosum smooth muscle myopotential (P < 0.01).
Conclusions:
The results indicate that corpus cavernosal nerve dysfunction may play an important role in the erectile dysfunction of diabetic rats.