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Related Experiment Videos

Shigella bacteremia: a retrospective study.

David Greenberg1, Shai Marcu, Rimma Melamed

  • 1Pediatric Infectious Disease Unit, Pediatric Department D, Soroka University Medical Center, Beer-Sheva, Israel.

Clinical Pediatrics
|July 17, 2003
PubMed
Summary
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This study identified risk factors and characteristics of Shigella bacteremia in children under 18. Shigella flexneri was the most common subspecies, with resistance to ampicillin and trimethoprim/sulfamethoxazole observed.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Microbiology

Background:

  • Shigella bacteremia is a serious infection, particularly in children.
  • Understanding risk factors and antimicrobial resistance is crucial for effective treatment.

Purpose of the Study:

  • To determine risk factors for Shigella bacteremia in pediatric patients.
  • To characterize clinical and laboratory findings associated with Shigella bacteremia.
  • To identify Shigella subspecies and their antibiotic susceptibility patterns.

Main Methods:

  • Retrospective study of pediatric patients (<18 years) with Shigella bacteremia from 1989-2001.
  • Analysis of clinical data, including age, weight gain, diarrhea duration, and hospitalization length.
  • Microbiological analysis of Shigella isolates, including subspecies identification and antibiotic susceptibility testing.

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Main Results:

  • Fifteen pediatric cases of Shigella bacteremia were identified.
  • The majority of isolates were Shigella flexneri (86.7%).
  • Common clinical features included failure to gain weight and prolonged diarrhea; no fatalities occurred.
  • Antibiotic susceptibility revealed resistance to ampicillin and trimethoprim/sulfamethoxazole, but susceptibility to ceftriaxone, ciprofloxacin, and gentamicin.

Conclusions:

  • Shigella flexneri is a significant cause of bacteremia in young children.
  • Antibiotic resistance patterns highlight the need for judicious antibiotic selection.
  • Early identification and appropriate management are essential for favorable outcomes in pediatric Shigella bacteremia.