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Viremia and extraintestinal infections in infants with rotavirus diarrhea

Ning Li1, Zhi-yuan Wang

  • 1Department of Pediatrics, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.

Di 1 Jun Yi Da Xue Xue Bao = Academic Journal of the First Medical College of PLA
|July 17, 2003
PubMed

Insights

Rotavirus (RV) viremia is possible in infants with diarrhea and may lead to extraintestinal infections. This study detected RV in the plasma of affected infants, suggesting intestinal migration to other organs.

Area of Science:

  • Pediatrics
  • Virology
  • Infectious Diseases

Background:

  • Rotavirus (RV) is a common cause of gastroenteritis in infants.
  • Extraintestinal manifestations of RV infection are not well understood.
  • The potential role of viremia in RV pathogenesis requires further investigation.

Purpose of the Study:

  • To investigate the presence of rotavirus (RV) viremia in infants with diarrhea.
  • To explore the association between RV viremia and extraintestinal involvement.
  • To determine if RV can spread from the intestines to other organs.

Main Methods:

  • Nested reverse transcriptase-PCR was used to detect RV genomes in infant plasma.
  • Mononuclear cells from a subset of infants were analyzed for RV.
  • In situ hybridization and indirect in situ PCR examined RV in vital organs of deceased infants.

Main Results:

  • Rotavirus (RV) viremia was detected in 4 out of 60 infants with RV diarrhea.
  • In one case, RV serotype III was identified in plasma without variation.
  • RV genomes were found in the intestines, liver, lung, and kidney of two non-surviving infants.

Conclusions:

  • Rotavirus (RV) viremia is a potential complication in infants with severe diarrhea.
  • RV may disseminate from the intestines to other organs via the bloodstream.
  • Viremia could contribute to extraintestinal manifestations in rotavirus infections.
Abstract

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