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Clinical evaluation of combined-modality therapy for bone metastasis of non-small-cell lung cancer
Xin-xu Li1, Tong-Chong Zhou, Jian Zhao
1Department of Surgery, Sanshui District Hospital of Traditional Chinese Medicine, Foshan 5281001, China. lxx_xnyy@163.com
Objective:
To compare the therapeutic effects of single- and combined-modality therapy on bone metastasis of non-small-cell lung cancer.
Methods:
Seventy patients with bone metastasis of non-small-cell lung cancer were treated with one of the therapeutic modalities of radiotherapy, radioisotope, chemotherapy or medication with Bonefos respectively, while another 71 cases received combined-modality therapy through different combinations of the already listed modalities.
Results:
The single modality of radiotherapy, radioisotope, chemotherapy and Bonefos had similar efficacy in treating the bone metastasis cases, which were 55.0%, 56.2%, 42.1% and 53.3% respectively, with a total efficacy rate of 51.4%. Combined-modality therapy proved to be much superior in terms of the total efficacy rate (76.0%, P <0.05), but the blood and the gastrointestinal toxicity was not significantly reduced as compared with that in single-modality group (P >0.05).
Conclusion:
The combined- modality therapy is more effective for treating bone metastasis of non-small-cell lung cancer than single-modality therapy.
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