Phenylpropanolamine-induced intraventricular hemorrhage

Area of Science:

• Neurology
• Toxicology
• Pharmacology

Background:

• Phenylpropanolamine (PPA) is a sympathomimetic agent historically used in decongestants and appetite suppressants.
• Intracranial hemorrhage (ICH) is a recognized but rare adverse effect associated with PPA use, particularly in Western populations.
• Limited data exists on PPA-induced ICH in India, highlighting a potential knowledge gap.

Observation:

• A case study of a patient in India who developed intraventricular hemorrhage (IVH) after ingesting PPA.
• The patient experienced symptoms consistent with a hemorrhagic stroke following PPA consumption.
• No prior reports of PPA-associated ICH from India were identified in the literature.

Findings:

• The patient's IVH was directly linked to PPA ingestion.
• The individual demonstrated a complete and uneventful recovery from the hemorrhage within two weeks.
• This case represents the first documented instance of PPA-induced IVH in the Indian subcontinent.

Implications:

• Highlights the neurotoxic potential of PPA, even in regions with limited prior reporting.
• Suggests the need for increased awareness among Indian healthcare providers regarding PPA as a potential cause of ICH.
• Underscores the importance of considering PPA in the differential diagnosis of spontaneous intracranial hemorrhage, especially in patients with a history of its use.