Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neuroprotection in glaucoma.

S Kaushik1, S S Pandav, J Ram

  • 1Department of Ophthalmology, Postgraduate Institute of medical education and Research, Chandigarh-160 012, India.

Journal of Postgraduate Medicine
|July 17, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multipronged strategy for protection and motivation of healthcare workers during the COVID-19 pandemic: a real-life study.

Antimicrobial stewardship & healthcare epidemiology : ASHE·2025
Same author

Post-radical hysterectomy ovarian torsion-A gynecological emergency: a case series.

Journal of medical case reports·2024
Same author

Utility of zero echo time (ZTE) sequence for assessing bony lesions of skull base and calvarium.

Clinical radiology·2024
Same author

Clinical effects of Lactobacillus reuteri probiotic in chronic periodontitis - a systematic review.

European review for medical and pharmacological sciences·2024
Same author

High prevalence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) antibodies among unvaccinated children of Chandigarh, Northwest India, in a household-based paediatric serosurvey post-second wave of pandemic (June to July 2021).

Public health·2023
Same author

<i>In-vitro</i> antiviral activity of <i>Carica papaya</i> formulations against dengue virus type 2 and chikungunya viruses.

Heliyon·2022
Same journal

Assessment of exclusive breastfeeding practices in a tribal district of Maharashtra: A cross-sectional study.

Journal of postgraduate medicine·2026
Same journal

Leveraging immersive technology with virtual emulation for training of nonmedico combatants: A randomized controlled trial.

Journal of postgraduate medicine·2026
Same journal

From clinic to microscope: A study of clinicopathological concordance in 5000 skin biopsies from a tertiary care center.

Journal of postgraduate medicine·2026
Same journal

Early anticoagulation with warfarin for pulmonary embolism complicating active gastric ulcer: A case against guideline-mandated delay.

Journal of postgraduate medicine·2026
Same journal

Paradoxical Hemophagocytic Lymphohistiocytosis to Stevens-Johnson Syndrome - Toxic Epidermal Necrolysis- A rare immune phenomenon.

Journal of postgraduate medicine·2026
Same journal

Anesthetic management of neonate with hypoplastic left heart syndrome posted for exploratory laparotomy.

Journal of postgraduate medicine·2026
See all related articles

Glaucoma causes retinal ganglion cell death. Neuroprotection strategies, including pharmacological and immunological approaches, aim to preserve vulnerable cells and slow disease progression.

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Cell Biology

Background:

  • Glaucoma is an optic neuropathy characterized by selective death of retinal ganglion cells (RGCs).
  • RGC death is a biphasic process involving primary injury and secondary degeneration due to a noxious cellular environment.
  • Mechanisms include hypoxia, excitotoxicity, and intracellular calcium increase, leading to apoptosis or necrosis.

Purpose of the Study:

  • To review cellular events in glaucomatous neurodegeneration.
  • To discuss potential neuroprotective agents for glaucoma treatment.
  • To explore both pharmacological and immunological neuroprotection strategies.

Main Methods:

  • Literature search of MEDLINE database.
  • Analysis of cellular events in RGC death.

Related Experiment Videos

  • Review of pharmacological agents with neuroprotective potential.

    • Main Results:

    • Glaucomatous neurodegeneration involves complex cellular cascades.
    • Pharmacological interventions aim to neutralize toxic factors and enhance neuronal resilience.
    • Immunological interventions leverage the body's repair mechanisms.

    Conclusions:

    • Neuroprotection is crucial for arresting glaucoma progression.
    • Both pharmacological and immunological strategies show promise for neuroprotection in glaucoma.
    • Further research into neuroprotective agents is warranted.