Non-high-density lipoprotein cholesterol and cardiovascular disease

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Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
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Vera Bittner1

  • 1Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA. vbittner@uab.edu

Current Opinion in Lipidology
|July 17, 2003
PubMed

Insights

Non-High-Density Lipoprotein (non-HDL) cholesterol is a strong predictor of cardiovascular risk. While its correlates and prognostic utility are established, the impact of treatment-induced changes on outcomes requires further investigation.

Area of Science:

  • Cardiovascular Medicine
  • Lipidology
  • Preventive Cardiology

Background:

  • Non-High-Density Lipoprotein (non-HDL) cholesterol is now a secondary therapeutic target.
  • Recent guidelines emphasize its importance in cardiovascular risk management.

Purpose of the Study:

  • To review correlates of non-HDL cholesterol levels.
  • To summarize data on non-HDL cholesterol as a predictor of cardiovascular events.
  • To examine the link between treatment-induced changes in non-HDL cholesterol and cardiovascular outcomes.

Main Methods:

  • Literature review of published reports.
  • Analysis of data on non-HDL cholesterol correlates.
  • Evaluation of prognostic utility studies.
  • Assessment of preliminary treatment outcome data.

Main Results:

  • Non-HDL cholesterol levels vary by demographics and are linked to adiposity, particularly visceral adiposity.
  • Non-HDL cholesterol is a potent predictor of cardiovascular risk across diverse populations.
  • Preliminary data suggest treatment-induced changes in non-HDL cholesterol may relate to prognosis.

Conclusions:

  • Non-HDL cholesterol is a significant predictor of cardiovascular risk and is prognostic.
  • Further research is needed to clarify the impact of pharmacologically induced changes in non-HDL cholesterol on cardiovascular outcomes.
Abstract

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