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HFE genotype and transferrin saturation in the United States
Mary E Cogswell1, Margaret L Gallagher, Karen K Steinberg
1Division of Nutrition and Physical Activity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, USA.
Purpose:
Examine the penetrance (defined by high transferrin saturation [TS]) of C282Y and H63D in the U.S. population.
Methods:
5171 participants from the Third National Health and Nutrition Examination Survey, 1992 to 1994.
Results:
77.1% (95% confidence interval [CI], 2.3, 95.1) of men and 51.9% (95% CI, 0, 84.2) of women with C282Y homozygosity had high TS. The associations of H63D homozygosity with high TS were stronger in people aged 50 years or older than in younger persons. Among Mexican-Americans, simple H63D heterozygosity was associated with high TS.
Conclusions:
The associations between HFE genotype and high TS may vary by sex, age, and ethnic group.