Related Experiment Video
Updated: Sep 23, 2026

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
Published on: May 29, 2020
Drug-induced autoimmunity
1Clinic for Rheumatology, University of Bern, Bern, Switzerland. werner.pichler@insel.ch
Purpose Of Review:
Presentation of different mechanism of drug-induced autoimmunity and highlighting of new developments.
Recent Findings:
Drugs can induce autoimmune diseases by their pharmacological properties. Injection of certain drugs into the thymus can alter positive selection in the thymus and elicit autoimmune reactions. Peripheral tolerance can be broken by increasing the expression of LFA-1 adhesion molecule on T cells. This can be related to the inhibition of intracellular kinases. Alternatively, a drug specific immune response might elicit autoimmunity by cross-reactivity: the drug reactive T cells might be cross-reactive with certain peptide antigens and possibly autoantigens.
Summary:
Drug-specific immune responses are well described. They have a great tendency to be cross-reactive with peptide antigens. This 'immunological' cause of autoimmunity elicited by drugs may occur more frequently than thought. It connects the field of drug hypersensitivity with drug-induced autoimmunity.
Related Concept Videos
Autoimmune Disorders
Concept and Mechanism of Autoimmune Diseases
The immune system...
Drug Toxicity: Allergic Reactions
Type I Diabetes I: Introduction
Allergic Drug Reactions
Type I Diabetes II: Pathophysiology
What is the Immune System?

