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Effects of fucoidan on chronic renal failure in rats
Quanbin Zhang1, Zhien Li, Zuhong Xu
1Institute of Oceanology, Chinese Academy of Sciences, Qingdao, P. R. China.
Planta Medica
|July 17, 2003
Abstract:
The effects of fucoidan on chronic renal failure (CRF) were investigated in vivo in a subtotal nephrectomy CRF model and a cryoinjury induced CRF model in rats. Fucoidan showed renoprotective effects in both models. Fucoidan (100 or 200 mg/kg, orally) significantly decreased elevated serum creatinine and urea nitrogen levels. Histopathological changes of renal tubules and interstitium were markedly alleviated by fucoidan and the mesangial areas were also greatly reduced. The activities of fucoidan were dose-dependent.