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Preparation of radioactively labeled dehydroxymethyl-epoxyquinomicin, an NF-kappa B function inhibitor
C Chaicharoenpong1, K Kato, K Umezawa
1Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-0061, Japan.
Drugs Under Experimental and Clinical Research
|July 18, 2003
Abstract:
Dehydroxymethylepoxyquinomicin (DHMEQ), a synthetic derivative of epoxyquinomicin C, is a potent and specific inhibitor of NF-kappa B in cultured cells. Tritium-labeled DHMEQ was synthesized with sodium borotritium. Specific radioactivity of the synthesized tritium-labeled DHMEQ was 15.45 mCi/mmol. This compound would be for the study of the mechanism of action and the stability of DHMEQ.