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Alkaline phosphatase in pleural effusions.

Mushtaq A Lone¹, Abdul Wahid, S M Saleem

¹Department of Medicine, S.K Institute of Medical Sciences, Srinagar, Kashmir, India.

The Indian Journal of Chest Diseases & Allied Sciences

|July 18, 2003

Summary

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Alkaline phosphatase in pleural fluid can help identify exudative effusions. Levels above 75 mg/dl suggest exudative pleural effusion, though it doesn't distinguish tuberculosis.

Area of Science:

Biochemistry
Pulmonology
Clinical Diagnostics

Background:

Pleural effusion (PF) is a frequent clinical finding across various diseases.
Identifying the cause of PF is crucial for effective treatment.
The diagnostic utility of pleural fluid parameters is variable.

Purpose of the Study:

To assess the diagnostic value of alkaline phosphatase (ALP) concentration in pleural effusions.
To determine if pleural fluid ALP can differentiate causes of pleural effusion.

Main Methods:

A study of 101 patients with pleural effusion over two years.
Diagnosis confirmation through pleural biopsy and cytology for malignant cells.

Main Results:

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Pleural fluid ALP levels exceeding 75 mg/dl were observed in exudative effusions.

Levels below 75 mg/dl were associated with transudative effusions.

ALP levels did not differentiate tuberculous pleural effusions from other exudative types.

Conclusions:

Pleural fluid alkaline phosphatase >75 mg/dl serves as a valuable biochemical marker for exudative effusions.
This marker aids in the initial classification of pleural effusions.