[The dynamic accumulation of a low-molecular physiologically active depressor factor and its biological effects in...

A low-molecular factor (800-1000 D) was isolated from the blood serum of dogs using selective ultrafiltration. That factor was taken in various terms of the hemorrhagic shock development. Biological activity of the factor was determined in experiments on isolated hearts of dogs and lymphoid cells. It is found that the above factor decreases the contractile function of the isolated heart, disturbs energy formation, inhibits the antibody-forming function of the spleen as well as possesses a cytolytic effect on lymphocytes of the peripheral blood lympho-nodes and thymus.