Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Infective Endocarditis in Intravenous Drug Abusers.

José M. Miró1, Asuncion Moreno, Carlos A. Mestres

  • 1*Infectious Diseases Service, Hospital Clinic--IDIBAPS, University of Barcelona, Villarroel, 170, 08036 Barcelona, Spain. miro@medicina.ub.es

Current Infectious Disease Reports
|July 18, 2003
PubMed
Summary

Infective endocarditis (IE) in intravenous drug abusers (IVDA) is often caused by Staphylococcus aureus and typically affects the tricuspid valve. Advances in antibiotic therapy and surgical techniques, including valve repair, offer good prognoses, even for HIV-infected individuals.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In vitro and in vivo activity of daptomycin plus ceftaroline for the treatment of experimental endocarditis due to Enterococcus faecalis with and without high-level aminoglycoside resistance.

The Journal of antimicrobial chemotherapy·2026
Same author

De Novo Cancer in Liver Transplant Patients With Human Immunodeficiency Virus Infection: A Multicenter Nationwide Cohort Study.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same author

In vitro activity of amoxicillin combined with oral cephalosporins against endocarditis-associated E. faecalis clinical isolates.

The Journal of antimicrobial chemotherapy·2026
Same author

False-Positive PET Uptake in Left Atrial Appendage Closure Devices Due to Postoperative Inflammatory Response.

Diagnostics (Basel, Switzerland)·2026
Same author

In vitro exebacase (CF-301) activity against methicillin-susceptible or methicillin-resistant Staphylococcus aureus and coagulase-negative staphylococci strains isolated from patients with infective endocarditis.

The Journal of antimicrobial chemotherapy·2025
Same author

Giants in infectious diseases: Prof. Jose M. Miró's translational research in infective endocarditis.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2025

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Public Health

Background:

  • Infective endocarditis (IE) is a severe complication for intravenous drug abusers (IVDA).
  • Staphylococcus aureus is the primary pathogen, usually affecting the tricuspid valve, with a generally good prognosis.
  • The HIV epidemic has influenced IE incidence in IVDA, possibly due to altered drug use behaviors.

Purpose of the Study:

  • To review recent advancements in the management of IE in IVDA.
  • To highlight progress in antibiotic therapy and surgical interventions.
  • To discuss the impact of HIV infection on IE outcomes in this population.

Main Methods:

  • Review of current literature on infective endocarditis in IVDA.
  • Analysis of treatment strategies, including antibiotic regimens and surgical options.

Related Experiment Videos

  • Evaluation of prognostic factors, particularly in the context of HIV co-infection.

    • Main Results:

    • Non-complicated Staphylococcus aureus right-sided endocarditis can be treated with a shorter course of antibiotics (nafcillin/cloxacillin plus aminoglycoside).
    • Surgery in HIV-infected IVDA does not negatively impact prognosis; tricuspid valvulectomy or repair is preferred over prosthetic material to prevent reinfection.
    • A cryopreserved mitral homograft offers atrioventricular competence, preventing right heart failure.
    • Mortality rates are similar between HIV-infected and non-HIV-infected IVDA, but higher in severely immunosuppressed HIV-positive individuals.

    Conclusions:

    • Effective antibiotic regimens and surgical techniques like valve repair or homograft replacement improve outcomes for IVDA with IE.
    • HIV status does not significantly alter overall mortality, but immunosuppression is a critical factor.
    • Continued research into the pathogenesis and management of IE in IVDA is essential.