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Third trimester glycemic profiles and fetal growth
Gustavo Leguizamón1, Francisco von Stecher
1Department of Obstetrics and Gynecology, High Risk Pregnancy Unit, Center of Medical Education and Clinical Research University, University of Buenos Aires, Galván 4102, Buenos Aires 1431, Argentina. gleguizamon@cemic.edu.ar
Current Diabetes Reports
|July 18, 2003
Summary
Third trimester hyperglycemia in pregnancy, both gestational and pregestational, impacts fetal growth. Optimal fetal growth requires a narrow glycemic control window, avoiding both high and excessively tight glucose levels.
Area of Science:
- Obstetrics and Gynecology
- Endocrinology
- Perinatology
Background:
- Diabetes in pregnancy, including gestational and pregestational, is a common complication.
- Third-trimester hyperglycemia is linked to abnormal fetal growth patterns.
Purpose of the Study:
- To investigate the relationship between blood glucose levels and fetal growth during pregnancy.
- To determine optimal glycemic targets for fetal growth in diabetic pregnancies.
Main Methods:
- Analysis of recent studies on postprandial glucose levels in normal pregnancy.
- Correlation of various blood glucose measurements with fetal growth parameters.
Main Results:
- Peak postprandial glucose levels in normal pregnancy are lower than previously estimated.
- One-hour postprandial glucose and overall mean blood glucose show the strongest correlation with fetal growth.
- Excessively tight glycemic control is associated with an increased incidence of small-for-gestational-age infants.
Conclusions:
- A narrow glycemic control window is crucial for optimal fetal growth.
- Current targets for managing diabetes in pregnancy may need adjustment based on new glucose level data.