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Updated: Sep 23, 2026

Primed Mycobacterial Uveitis (PMU) as a Model for Post-Infectious Uveitis
Published on: December 17, 2021
Infliximab in the treatment of refractory posterior uveitis
Annie Joseph1, Dev Raj, Harminder S Dua
1Department of Ophthalmology and Visual Sciences, B Floor, Eye and ENT Block, Queen's Medical Centre, Nottingham NG7 2UH, United Kingdom.
Purpose:
To determine the efficacy and safety of infliximab in the treatment of refractory posterior uveitis.
Design:
Noncomparative interventional case series.
Participants:
Five patients with posterior uveitis were treated: 3 had Behçet's syndrome, and 2 had idiopathic posterior uveitis.
Interventions:
Patients with sight-threatening uveitis refractory to other immunosuppressive agents were treated with infliximab.
Main Outcome Measures:
Intraocular inflammation, by using binocular indirect ophthalmoscopy score, retinal vasculitis, and visual acuity. Adverse effects of infliximab were documented.
Results:
Within 2 weeks of the first infusion of infliximab, 4 of 5 patients showed marked improvement in vitreous haze and visual acuity. By the 6-month follow-up, the same four patients had achieved remission of posterior uveitis and had successfully withdrawn all other immunosuppressive therapy. Further infusions of infliximab were required in 3 patients. One patient developed ocular and systemic tuberculosis, which responded to antituberculous treatment.
Conclusions:
Infliximab is effective in the treatment of sight-threatening refractory posterior uveitis. However, patients should be thoroughly screened for tuberculosis before treatment and followed up closely during and after therapy with infliximab.
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