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Related Experiment Videos

Grey literature in meta-analyses.

Vicki S Conn1, Jeffrey C Valentine, Harris M Cooper

  • 1Department of Psychological Sciences, University of Missouri-Columbia, USA. conn@missouri.edu

Nursing Research
|July 18, 2003
PubMed
Summary
This summary is machine-generated.

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Including grey literature in meta-analyses is crucial. Excluding it leads to over-representation of significant findings and inflated effect size estimates, compromising overall research accuracy.

Area of Science:

  • Biostatistics
  • Research Methodology
  • Evidence Synthesis

Background:

  • Meta-analysis combines individual study results for cumulative conclusions.
  • Grey literature, including unpublished studies, is sometimes included but faces validity concerns.
  • Peer review status of grey literature raises questions about its data quality.

Purpose of the Study:

  • To evaluate the necessity of including grey literature in meta-analyses.
  • To explore strategies for managing grey literature in quantitative synthesis.
  • To assess if published studies represent broader research findings.

Main Methods:

  • Review of evidence on the representativeness of peer-reviewed studies versus broader research.
  • Examination of strategies for improving access to grey literature.

Related Experiment Videos

  • Analysis of methodological rigor in published versus grey literature.
  • Main Results:

    • Published research disproportionately reports statistically significant results compared to grey literature.
    • Effect size estimates in published studies are approximately one-third larger than in unpublished studies.
    • Methodological rigor is comparable between published and grey literature, with smaller or unfunded studies less likely to be published.

    Conclusions:

    • Excluding grey literature from meta-analyses overestimates statistically significant findings and inflates effect sizes.
    • Meta-analyses including grey literature provide more accurate and precise effect size estimates.
    • Inclusion of grey literature is recommended to fully represent the evidential base, with moderator analysis for methodological variations.