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Updated: Sep 23, 2026

Generating a Fractal Microstructure of Laminin-111 to Signal to Cells
Published on: September 28, 2020
[Cryptic sites and matrikines: cellular effects of fibronectin and laminin peptides]
1Laboratoire de Recherche Ophtalmologique, Hôpital de l'Hôtel-Dieu, 1, place du parvis Notre Dame, 75181 Paris.
Abstract:
Structural glycoproteins such as fibronectin and laminin play a dual role in the organisation of extracellular matrix and by acting through integrins with cell surfaces. Cell-matrix interactions are crucial for the regulation of cell behaviour which depends strictly on matrix composition. Structural glycoproteins do contain cryptic sites which can be revealed during fibrillogenesis, adsorption, alteration of conformation and proteolysis. Fibronectin and laminin fragments present new properties by comparison with the native molecule. Matrix remodeling and production of matrikins were shown to be of great importance for cell differentiation and cell behaviour and in pathological conditions.
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