[Optimization criteria in intensity-modulated radiotherapy]

The present paper provides an overview on the inverse treatment planning for the assessment of intensity-modulated fields. The problem is to find the optimal dose distribution for given attributes of the irradiated tissue. The attributes of the optimal dose distribution are delineated by an objective function. In practice, models are used that evaluate the physical dose distribution, either directly or through their radiobiological effects. In the simplest case, the squared deviation of the achieved dose distribution is minimized to the prescribed dose distribution. For organs structured in parallel, it is common to introduce dose-volume constraints. Another approach is to optimize a value for the probability of complication-free tumor control. The complication probability for normal tissue, in turn, is a rather complex function. However, using the relative seriality, a simple model can be devised with a certain approximation. Other models of "effective dose" are also presented.