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[Testing cross-calibration between positron emission tomographs and their peripheral devices]
Lilli Geworski1, Bernd O Knoop, Michael Hofmann
1Klinik für Nuklearmedizin, Universitätsklinikum Charité der Humboldt-Universität zu Berlin. lilli.geworski@charite.de
Zeitschrift Fur Medizinische Physik
|July 19, 2003
Summary
Cross-calibration of positron emission tomographs (PET) and peripheral devices is crucial for multicenter studies. This study found significant deviations, highlighting the need for stringent quality control in quantitative imaging research.
Area of Science:
- Nuclear Medicine
- Medical Imaging Physics
Context:
- Multicenter clinical studies require precise and consistent quantitative imaging data.
- Positron Emission Tomography (PET) scanners and associated peripheral devices (dose calibrators, sample changers) are essential for radiotracer quantification.
- Variability in instrumentation can compromise data integrity and comparability across sites.
Purpose:
- To assess the cross-calibration accuracy of PET scanners and their peripheral devices.
- To identify potential sources of error prior to a large-scale multicenter PET study.
- To establish baseline performance metrics for quantitative PET imaging.
Summary:
- Twenty-four PET scanners across 22 sites were evaluated for cross-calibration with dose calibrators and sample changers using standardized protocols.
- Deviations between PET scanners and dose calibrators were observed, with some exceeding 10% in both 2D and 3D modes.
- Peripheral devices like dose calibrators and well counters showed generally acceptable cross-calibration errors, mostly below 10%.
Impact:
- Highlights the critical need for rigorous cross-calibration procedures in multicenter PET studies.
- Identifies specific areas of instrumentation that may require recalibration or improved standardization.
- Emphasizes the importance of quality assurance for reliable quantitative data in multicenter clinical trials.