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Updated: Sep 23, 2026

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis
Published on: May 23, 2021
Treatment of human brucellosis with rifampin plus minocycline
A Cascio1, F Scarlata, S Giordano
1AILMI (Associazione Italiana per la Lotta contro le Malattie Infettive) c/o Scuola di Specializzazione in Malattie Infettive Università di Messina, Via Consolare Valeria n.1, 98125 Messina, Italy. acascio@unime.it
Abstract:
In order to evaluate the efficacy and tolerability of a high intravenous dose of rifampin plus oral minocycline (administered daily for 3 weeks) for the treatment of acute brucellosis, we retrospectively reviewed the outcome of 239 consecutive patients (135 adults and 104 children) diagnosed and treated over a 17-year period in Italy. The combination used resulted in 100% response and a relapse rate lower than 2%. Fifty-two (30 adults and 22 children) (29.8%) complained of mild adverse effects including an increase in aspartate aminotransferase (>250 IU) observed in 12 cases and considered related to rifampin and in 11 cases a reversible hyperpigmentation of the tongue attributed to minocycline. A randomized prospective comparative study should be performed to confirm our encouraging results.
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