Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Simple one-flask method for the preparation of hydroxamic acids.

Giampaolo Giacomelli1, Andrea Porcheddu, Margherita Salaris

  • 1Dipartimento di Chimica, Università degli Studi di Sassari, via Vienna 2, I-07100 Sassari, Italy. ggp@uniss.it

Organic Letters
|July 19, 2003
PubMed
Summary

A novel one-step method efficiently converts carboxylic acids to hydroxamic acids under mild conditions. This approach is valuable for synthesizing enantiopure hydroxamates from amino acids and peptides.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechanochemistry Meets Catalysis: Metal Complexes for Greener Organic Transformations.

Angewandte Chemie (International ed. in English)·2026
Same author

Wool-supported Pd and Rh nanoparticles for selective hydrogenation of maleic acid to succinic acid in batch and flow systems.

RSC advances·2025
Same author

Caulerpin Delivery via Pluronic-Free Cubosomes: Unlocking the Therapeutic Potential of a Pigment from an Invasive Marine Algae.

Molecular pharmaceutics·2025
Same author

Beyond Simple Grinding: Methylammonium Chloride Promotes Sustainable, Cylinder-Free Mechanochemical Synthesis of Deferiprone.

ChemSusChem·2025
Same author

Mechanochemistry-Driven Borrowing Hydrogen Processes for Ru-Catalyzed N-Alkylation: A Pathway to Enhanced Sustainability and Efficiency.

Angewandte Chemie (International ed. in English)·2025
Same author

Delivery of Ulva rigida extract by bicontinuous cubic lipid nanoplatforms for potential photodynamic therapy against pancreatic cancer.

Colloids and surfaces. B, Biointerfaces·2025

Area of Science:

  • Organic Chemistry
  • Synthetic Chemistry

Background:

  • Hydroxamic acids are important functional groups in medicinal chemistry and natural products.
  • Traditional synthesis of hydroxamic acids often requires harsh conditions or multiple steps.

Purpose of the Study:

  • To develop a simple, efficient, and mild one-step method for converting carboxylic acids to hydroxamic acids.
  • To apply this method for the synthesis of enantiopure hydroxamates derived from alpha-amino acids and peptides.

Main Methods:

  • A one-step reaction protocol was established for the direct conversion of carboxylic acids.
  • The reaction conditions were optimized for mildness and efficiency.
  • The method was applied to synthesize hydroxamates from chiral alpha-amino acids and peptide fragments.

Related Experiment Videos

Main Results:

  • Successfully demonstrated a one-step conversion of various carboxylic acids to their corresponding hydroxamic acids.
  • Achieved high yields and preserved the stereochemistry of the starting materials.
  • Synthesized enantiopure hydroxamate derivatives of alpha-amino acids and small peptides.

Conclusions:

  • The developed method offers a straightforward and mild route to hydroxamic acids.
  • This new synthetic strategy is particularly useful for preparing enantiopure hydroxamates, expanding access to valuable chemical entities.