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Fluoroquinolone therapy and Achilles tendon rupture
Diane Vanek1, Amol Saxena, John M Boggs
1California School of Podiatric Medicine, San Francisco, CA, USA.
Journal of the American Podiatric Medical Association
|July 19, 2003
Summary
Fluoroquinolone antibiotics, like ciprofloxacin, may increase the risk of Achilles tendinopathy. Athletes and exercisers should be aware of this potential side effect, even when taking antibiotics for other infections.
Area of Science:
- Pharmacology
- Orthopedics
- Infectious Disease
Background:
- Fluoroquinolones are broad-spectrum antibiotics.
- Tendinopathies, including Achilles tendinopathy, are common musculoskeletal injuries.
Observation:
- Three cases of Achilles tendinopathy were observed.
- These cases followed treatment with ciprofloxacin for unrelated bacterial infections.
Findings:
- Ciprofloxacin treatment preceded the onset of Achilles tendinopathy symptoms in all three cases.
- The exact mechanism linking fluoroquinolones to tendinopathy remains unclear.
Implications:
- Individuals engaging in sports or exercise should be informed about the potential risk of fluoroquinolone-induced tendinopathy.
- Further research is needed to elucidate the mechanism of this adverse drug reaction.