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Updated: Oct 23, 2026

Synovial Fluid Analysis to Identify Osteoarthritis
Published on: October 20, 2022
Functional deficiency of antigen-presenting cells in the synovial fluid of rheumatoid arthritis
A Iglesias1, H Deulofeut, D P Dubey
1Dana-Farber Cancer Institute, Boston, Massachusetts 02115.
Abstract:
In our study of rheumatoid arthritis (RA) patients, we observed a decrease of tetanus toxoid antigen-presenting capacity of synovial fluid (SF) adherent cells to autologous T cells of either SF or peripheral blood. Additionally, we found a higher capacity of adherent synovial cells to stimulate autologous T-lymphocytes. Our results suggest that antigen-presenting cells of the SF of RA patients have defects that may play a role in defective presentation of antigens in joints and may account for other abnormal functions important in the pathogenesis of RA.
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