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Artificial surfaces in apheresis devices: interactions with the complement system.

P S Malchesky1

  • 1Cleveland Clinic Foundation, Department of Biomedical Engineering and Applied Therapeutics, Ohio.

Journal of Clinical Apheresis
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

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Artificial surfaces activate the complement system in blood, altering cellular function. Anticoagulant choice also impacts this activation, suggesting material design can tailor blood responses for therapy.

Area of Science:

  • Biomaterials Science
  • Immunology
  • Hematology

Background:

  • Blood contact with artificial surfaces triggers complement activation.
  • This activation leads to changes in blood cell concentration and function.
  • The type of anticoagulant used influences the extent of complement activation.

Purpose of the Study:

  • To investigate the impact of artificial surfaces on complement activation.
  • To understand how anticoagulants affect blood-biomaterial interactions.
  • To explore the potential for material design to modulate blood responses.

Main Methods:

  • Exposure of blood to various artificial surfaces.
  • Analysis of complement activation markers.
  • Assessment of cellular changes (concentration and function).

Related Experiment Videos

  • Evaluation of different anticoagulant types.

    • Main Results:

    • Artificial surfaces induce varying degrees of complement activation.
    • Complement activation is linked to significant cellular concentration and functional alterations.
    • The choice of anticoagulant demonstrably affects complement activation levels.
    • Biomaterials exhibit a biomodulating effect on blood components.

    Conclusions:

    • Material choice and design are critical for managing blood-biomaterial interactions.
    • Biocompatibility can be engineered to achieve desired humoral and cellular responses.
    • Tailoring material properties can influence therapeutic outcomes in blood-contacting applications.