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Proteomics approaches to elucidation of signal transduction pathways
Jasminka Godovac-Zimmermann1, Larry R Brown
1Centre for Molecular Medicine, Department of Medicine, University College London, 5 University Street, London, WC1E 6JJ, UK. j.godovac-zimmermann@ucl.ac.uk
Current Opinion in Molecular Therapeutics
|July 23, 2003
Abstract:
Recent applications have shown that proteomics can provide crucial new information regarding cellular signaling processes. Bottom-up and small-scale top-down proteomics approaches related to routine biochemical methods have become widely applied to identify new aspects of established signaling pathways. Top-down, global proteomics methods are developing rapidly and are beginning to deliver information on global integration of signaling processes that has been difficult to obtain with conventional approaches.