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Mediators in HIV-associated cardiovascular disease: a focus on cytokines and genes

Stacy D Fisher1, Neil E Bowles, Jeffrey A Towbin

  • 1Department of Medicine, Cardiology Unit, University of Rochester Medical Center, Rochester, New York 14642, USA.

AIDS (London, England)
|July 23, 2003
PubMed

Insights

As people with HIV live longer, heart failure is a growing concern. This review explores how cytokines and genes impact HIV-associated heart failure, aiding diagnosis and treatment.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Genetics

Background:

  • Increasing longevity in individuals with HIV has led to a rise in late-onset health complications.
  • Cardiovascular disease, particularly symptomatic heart failure, is emerging as a significant health issue in the aging HIV-infected population.

Purpose of the Study:

  • To review the potential cytokine and gene-mediated mechanisms contributing to HIV-associated cardiovascular illness.
  • To explore how understanding these mechanisms can inform the diagnosis, management, and therapy of HIV-associated heart failure.

Main Methods:

  • Literature review of studies investigating cytokine and genetic factors in HIV-associated cardiovascular disease.
  • Synthesis of current knowledge on the role of inflammatory mediators and genetic predispositions.

Main Results:

  • Cytokines and specific gene expressions are implicated in the pathogenesis of HIV-associated cardiovascular complications.
  • These molecular pathways may influence the development and progression of heart failure in HIV-infected individuals.

Conclusions:

  • Understanding cytokine and gene-mediated effects is crucial for advancing the diagnosis and treatment of HIV-associated heart failure.
  • Targeting these pathways may offer novel therapeutic strategies for managing cardiovascular complications in long-term HIV survivors.

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