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Updated: Sep 23, 2026

Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants
Published on: March 29, 2018
Factors involved in the aetiology of molar-incisor hypomineralisation (MIH)
V E Beentjes1, K L Weerheijm, H J Groen
1Department of Cariology Endodontology Pedodontology Academic Centre for Dentistry (ACTA), Amsterdam, The Netherlands.
Abstract:
AIM: This study aimed to collect more information on factors associated with molar-incisor hypomineralisation (MIH), which is a frequent developmental enamel defect with unknown aetiology. MATERIALS AND METHODS: A questionnaire was sent to the parents of 45 children (average age 9.9 years; SD+/-2.02), 24 with affected first molars and 21 controls. The two groups of children were similar in terms of age, gender and living conditions. Questions were asked about the health of mother and child during pregnancy, the birth and health of the child up to age four years. RESULTS: Birth weight and length in the two groups of children were similar, as was the duration of breast- and/or bottle-feeding and the incidence of complications during pregnancy and birth. The children with MIH were ill more frequently during the first four years of life. CONCLUSION: Knowledge of the type of disease that might be involved in the development of such molars is still inadequate, but there appears to be an association with pneumonia, otitis media and high fevers.
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