Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cartilage regeneration by gene therapy.

K Gelse1, K von der Mark, H Schneider

  • 1Nikolaus Fiebiger Center of Molecular Medicine, Dept. of Experimental Medicine I, University of Erlangen-Nuernberg, Germany. hschneid@molmed.uni-erlangen.de

Current Gene Therapy
|July 23, 2003
PubMed
Summary

Gene therapy offers promising strategies for articular cartilage repair by delivering therapeutic molecules like growth factors to stimulate chondrogenesis. This approach aims to improve cartilage regeneration and overcome limitations of current surgical methods.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structural analysis of lipooligosaccharide produced by Neisseria gonorrhoeae, strain MS11mk (variant A): a precursor for a gonococcal lipooligosaccharide associated with virulence.

Biochemistry·1992
Same author

[Surveillance of the incidence of diabetes mellitus in a rural area of Mecklenburg-Vorpommern].

Zeitschrift fur arztliche Fortbildung·1992
Same author

Vascular beta-adrenoceptor-mediated responses in hypertension and ageing in rats.

Journal of autonomic pharmacology·1992
Same author

27Al satellite transition spectroscopy (SATRAS) of polycrystalline aluminum borate 9Al2O3.2B2O3.

Solid state nuclear magnetic resonance·1992
Same author

[Acute intermittent porphyria in pregnancy: glucose or hematin therapy?].

Schweizerische medizinische Wochenschrift·1992
Same author

[Induction of labor with a new intracervically administered prostaglandin E2 gel. Report of initial experience].

Geburtshilfe und Frauenheilkunde·1992

Area of Science:

  • Regenerative Medicine
  • Molecular Biology
  • Orthopedic Surgery

Background:

  • Articular cartilage damage is a significant clinical challenge, often resulting in irreversible defects and poor repair quality.
  • Current surgical interventions struggle to fully restore articular surfaces, leading to incomplete chondrogenesis or rapid tissue degradation.
  • Advances in molecular biology highlight the potential of therapeutic molecules in directing cartilage cell differentiation and matrix synthesis.

Purpose of the Study:

  • To review therapeutic molecules for cartilage repair, including anabolic and anti-catabolic factors.
  • To assess the suitability of viral and non-viral vectors for intraarticular gene transfer.
  • To summarize findings from gene therapy studies in animal models for cartilage repair.

Main Methods:

Related Experiment Videos

  • Review of scientific literature on growth factors, cytokines, and gene therapy for cartilage repair.
  • Analysis of anabolic factors (e.g., TGF-beta superfamily, IGF-1, FGF, HGF) and anti-catabolic molecules (e.g., IL-4, IL-10, IL-1Ra, TNFsR).
  • Evaluation of viral and non-viral vectors for intraarticular gene delivery and outcomes in animal models.

Main Results:

  • Anabolic factors show potential in stimulating chondrogenesis and hyaline cartilage-like tissue formation in experimental settings.
  • Anti-catabolic and anti-inflammatory molecules may inhibit cartilage degradation, contributing to repair.
  • Gene therapy, combined with chondroprogenitor cells, offers a sustained delivery method for therapeutic factors in vivo.

Conclusions:

  • Therapeutic molecules and gene therapy represent promising tools for enhancing articular cartilage repair.
  • While complete regeneration of hyaline cartilage remains challenging, these approaches can improve repair tissue quality.
  • Intraarticular gene transfer holds potential for sustained delivery of therapeutic agents, advancing cartilage regeneration strategies.