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Urokinase receptor and integrin interactions.

Matthias C Kugler¹, Ying Wei, Harold A Chapman

¹Department of Medicine, Pulmonary and Critical Care Division, and CVRI University of California, San Francisco, 94143, USA.

Current Pharmaceutical Design

|July 23, 2003

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Urokinase receptors (uPAR) are key signaling partners with integrins in cell adhesion and migration. Targeting uPAR:integrin interactions may offer new strategies for treating diseases like tumor metastasis.

Area of Science:

Cell Biology
Molecular Biology
Biochemistry

Background:

Urokinase receptors (uPAR) were initially considered solely for concentrating the urokinase/plasmin system.
Emerging evidence highlights uPAR's crucial roles in the adhesive and signaling pathways of migratory cells.

Purpose of the Study:

To investigate the functional significance of uPAR's interactions with other membrane proteins, particularly integrins.
To explore the structural and functional implications of uPAR:integrin complexes in cell migration.

Main Methods:

Analysis of uPAR:integrin interactions at the cell surface.
In vivo studies to assess the impact of impaired uPAR:integrin interactions on cell migration.

Main Results:

Related Experiment Videos

uPAR acts as a cis-acting integrin ligand, with specific structural features governing their interaction.
Disruption of uPAR:integrin interactions leads to altered integrin function and impaired cell migration.

Conclusions:

uPAR-integrin interactions are critical for cell adhesion and migration.
These interactions represent a potential therapeutic target for pathobiological conditions involving integrin dysfunction, such as tumor metastasis.