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A possible target of antioxidative therapy for diabetic vascular complications-vascular NAD(P)H oxidase

T Inoguchi1, H Tsubouchi, T Etoh

  • 1Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. toyoshi@intmed3.med.kyushu-u.ac.jp

Current Medicinal Chemistry
|July 23, 2003
PubMed

Insights

Diabetic vascular complications may stem from oxidative stress caused by increased reactive oxygen species (ROS) production. Targeting NAD(P)H oxidase offers a potential antioxidative therapy strategy for diabetes.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Vascular Biology

Background:

  • Oxidative stress is implicated in diabetic vascular complications.
  • The precise molecular mechanisms of increased reactive oxygen species (ROS) in diabetes are not fully understood.
  • NAD(P)H oxidase is increasingly recognized as a significant source of ROS in vascular cells.

Purpose of the Study:

  • To review the role of NAD(P)H oxidase in diabetic vascular complications.
  • To explore the molecular mechanisms of ROS production in diabetes.
  • To discuss antioxidative therapy strategies targeting NAD(P)H oxidase.

Main Methods:

  • Review of existing literature on oxidative stress and diabetes.
  • Analysis of studies investigating NAD(P)H oxidase activity and expression in diabetic models.
  • Examination of the role of protein kinase C (PKC) in high glucose-induced ROS production.

Main Results:

  • High glucose stimulates ROS production via PKC-dependent activation of vascular NAD(P)H oxidase.
  • Increased expression of NAD(P)H oxidase components is observed in diabetic animal vascular tissues.
  • These changes correlate with functional disorders and histochemical abnormalities in diabetic vasculature.

Conclusions:

  • Vascular NAD(P)H oxidase-driven ROS production likely contributes to diabetic micro- and macrovascular complications.
  • Targeting NAD(P)H oxidase represents a potential therapeutic strategy for managing diabetic vascular disease.
  • Further research into antioxidative therapies for diabetic complications is warranted.

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