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Molecular modeling of the neurohypophyseal receptor/atosiban complexes
Magdalena J Slusarz1, Rafał Slusarz, Rajmund Kaźmierkiewicz
1Faculty of Chemistry, University of Gdán sk, Sobieskiego 18, 80-952 Gdańsk, Poland.
Protein and Peptide Letters
|July 23, 2003
Abstract:
The neurohypophyseal nonapeptide hormone oxytocin (OT) is the strongest uterotonic substance known and is responsible for the initiation of labor. Conversely, oxytocin antagonists blocking uterine OT receptor can suppress uterus contraction. In this paper we describe a computer simulated docking pertinent to affinity of an oxytocin antagonist atosiban towards OT receptor, versus vasopressin V1a and V2 receptors.