Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Magnetic resonance direct thrombus imaging.

A R Moody1

  • 1Department of Medical Imaging, Sunnybrook and Women's College, Health Sciences Center, Toronto, Canada. alan.moody@sw.ca

Journal of Thrombosis and Haemostasis : JTH
|July 23, 2003
PubMed
Summary

Magnetic Resonance Direct Thrombus Imaging (MRDTI) detects subacute thrombosis by identifying methemoglobin, an endogenous contrast agent. This non-invasive MRI technique aids in diagnosing venous thromboembolic disease and identifying high-risk arterial plaque.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cross-sectional and longitudinal Biomarker extraction and analysis for multicentre FLAIR brain MRI.

Neuroimage. Reports·2025
Same author

FLAIR MRI biomarkers of the normal appearing brain matter are related to cognition.

NeuroImage. Clinical·2022
Same author

Roadmap Consensus on Carotid Artery Plaque Imaging and Impact on Therapy Strategies and Guidelines: An International, Multispecialty, Expert Review and Position Statement.

AJNR. American journal of neuroradiology·2021
Same author

Pathology-preserving intensity standardization framework for multi-institutional FLAIR MRI datasets.

Magnetic resonance imaging·2019
Same author

Carotid Artery Wall Imaging: Perspective and Guidelines from the ASNR Vessel Wall Imaging Study Group and Expert Consensus Recommendations of the American Society of Neuroradiology.

AJNR. American journal of neuroradiology·2018
Same author

Carotid atherosclerotic calcification does not result in high signal intensity in MR imaging of intraplaque hemorrhage.

AJNR. American journal of neuroradiology·2010

Area of Science:

  • Biomedical Imaging
  • Vascular Medicine
  • Radiology

Background:

  • Blood clots undergo predictable stages related to hemoglobin oxygenation.
  • Methemoglobin formation occurs during clot aging and acts as an endogenous contrast agent.
  • Magnetic Resonance Direct Thrombus Imaging (MRDTI) leverages this property for clot detection.

Purpose of the Study:

  • To evaluate the utility of MRDTI in detecting various forms of thrombosis.
  • To highlight MRDTI's potential in identifying high-risk vascular disease.
  • To explore MRDTI's application in monitoring therapeutic interventions.

Main Methods:

  • Utilizing T1-weighted magnetic resonance sequences for imaging.
  • Employing methemoglobin's high signal intensity as a contrast mechanism.

Related Experiment Videos

  • Applying MRDTI across diverse clinical settings including venous and arterial systems.

    • Main Results:

    • MRDTI effectively detects subacute thrombosis in deep vein thrombosis and pulmonary embolism.
    • The technique visualizes thrombosis in the peripheral arterial tree.
    • MRDTI identifies complicated atherosclerotic plaque in carotid arteries, indicative of vulnerable plaque.

    Conclusions:

    • MRDTI is a valuable, non-invasive imaging modality for detecting venous thromboembolic disease.
    • MRDTI aids in identifying high-risk cerebrovascular atherosclerosis prior to end-organ damage.
    • The technique shows promise for research applications, including monitoring vascular disease treatments.