Ligand-selective receptor conformations revisited: the promise and the problem

Receptor kinetics: Binding flux-based approaches offer complementary insight into how ligand binding evolves with time.

British journal of pharmacology·2026

Effects of diffusion, affinity, and permeation rate on drug cell therapy.

Journal of receptor and signal transduction research·2026

Biased Signaling as Allosteric Probe Dependence: Everything Old Is New Again.

Biochemistry·2026

Therapeutic implications of target residence time.

Current opinion in structural biology·2026

Structure-based design of an opioid receptor modulator for enhanced morphine analgesia.

Science advances·2026

Differential Effects of Sodium on Agonist-Induced Conformational Transitions and Signaling at μ and κ Opioid Receptors.

Biochemistry·2025

Tau-targeting pharmacological strategies in neurodegenerative disease.

Trends in pharmacological sciences·2026

Sequential EGFR inhibition sensitizes glioblastoma to temozolomide.

Trends in pharmacological sciences·2026

Reprogramming pain signaling through photopharmacology.

Trends in pharmacological sciences·2026

Lysosome-targeted protein degradation platforms for spatiotemporally controlled degradation.

Trends in pharmacological sciences·2026

Sex-sensitive serotonergic signaling in psychedelic pharmacology.

Trends in pharmacological sciences·2026

Amyloidogenic amylin signaling links diabetes to dementia pathogenesis.

Trends in pharmacological sciences·2026

Artificial intelligence-guided discovery of marine scalaranes as selective COX-2 inhibitors through machine learning and molecular modelling.

Organic & biomolecular chemistry·2026

Synthesis and preclinical validation of 5HT1A receptor-targeted carbon dots functionalized with Gd3+ and 99mTc as a multi-modal SPECT and MRI probe for molecular imaging.

Nanoscale·2026

Fluorescent NHC Gold(I) Complexes as Tools for Target Identification and Metallomic Studies in Cancer Cells.

Inorganic chemistry·2026

Computational and Experimental Approaches for HPMCAS-Based Solid Dispersions of Abiraterone Acetate: Formulation, Characterization, and Biopharmaceutical Enhancement Evaluation.

Drug development and industrial pharmacy·2026

Vertical Multi-Target Design of Potential Staphylococcus aureus Respiratory Inhibitors: A Systematic in Silico Fragment-Based Approach.

Omics : a journal of integrative biology·2026

M2-PRNet: Multi-Scale and Multi-Modal Learning for Protein-RNA Binding Affinity Prediction.

Bioinformatics (Oxford, England)·2026

Related Experiment Videos

Ligand-selective receptor conformations revisited: the promise and the problem

Related Concept Videos

Receptor kinetics: Binding flux-based approaches offer complementary insight into how ligand binding evolves with time.

Effects of diffusion, affinity, and permeation rate on drug cell therapy.

Biased Signaling as Allosteric Probe Dependence: Everything Old Is New Again.

Therapeutic implications of target residence time.

Structure-based design of an opioid receptor modulator for enhanced morphine analgesia.

Differential Effects of Sodium on Agonist-Induced Conformational Transitions and Signaling at μ and κ Opioid Receptors.

Tau-targeting pharmacological strategies in neurodegenerative disease.

Sequential EGFR inhibition sensitizes glioblastoma to temozolomide.

Reprogramming pain signaling through photopharmacology.

Lysosome-targeted protein degradation platforms for spatiotemporally controlled degradation.

Sex-sensitive serotonergic signaling in psychedelic pharmacology.

Amyloidogenic amylin signaling links diabetes to dementia pathogenesis.

Artificial intelligence-guided discovery of marine scalaranes as selective COX-2 inhibitors through machine learning and molecular modelling.

Synthesis and preclinical validation of 5HT1A receptor-targeted carbon dots functionalized with Gd3+ and 99mTc as a multi-modal SPECT and MRI probe for molecular imaging.

Fluorescent NHC Gold(I) Complexes as Tools for Target Identification and Metallomic Studies in Cancer Cells.

Computational and Experimental Approaches for HPMCAS-Based Solid Dispersions of Abiraterone Acetate: Formulation, Characterization, and Biopharmaceutical Enhancement Evaluation.

Vertical Multi-Target Design of Potential Staphylococcus aureus Respiratory Inhibitors: A Systematic in Silico Fragment-Based Approach.

M2-PRNet: Multi-Scale and Multi-Modal Learning for Protein-RNA Binding Affinity Prediction.

Related Experiment Videos

Ligand-selective receptor conformations revisited: the promise and the problem

Related Concept Videos

Related Articles